This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
5-AMINO-1MQ
$
139 AUD
Product Info
5-Amino-1MQ is a small-molecule research compound commonly studied for its interaction with nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and methylation pathways. It is used in laboratory research to explore metabolic regulation, energy balance, and biochemical signalling processes. Due to its defined molecular structure and stability, 5-Amino-1MQ is of interest in controlled experimental settings focused on enzymatic activity and metabolic studies. This compound is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Categories
Bacteriostatic Water
AOD
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Cagrilintide + Semaglutide
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Semaglutide
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SLU PP 332
MOTS C
BPC 157
bpc-157-tb-500
Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
5-Amino-1MQ is a small molecule amine compound designed as an inhibitor of nicotinamide N-methyltransferase (NNMT) enzyme. The compound blocks NAD+ depletion and enhances cellular NAD+ availability, supporting metabolic health, energy production, and mitochondrial function. 5-Amino-1MQ is extensively studied for its potential in supporting metabolic flexibility, energy expenditure, and body composition improvement. Research indicates the compound inhibits NNMT-mediated NAD+ depletion, enhances NAD+-dependent sirtuin signaling, and promotes metabolic adaptations similar to caloric restriction and exercise. 5-Amino-1MQ represents a valuable research tool for investigating NAD+ metabolism, NNMT inhibition, metabolic regulation, and therapeutic approaches to metabolic dysfunction and obesity.
Overview
5-Amino-1MQ is a small molecule amine compound designed as an inhibitor of nicotinamide N-methyltransferase (NNMT) enzyme. The compound blocks NAD+ depletion and enhances cellular NAD+ availability, supporting metabolic health, energy production, and mitochondrial function. 5-Amino-1MQ is extensively studied for its potential in supporting metabolic flexibility, energy expenditure, and body composition improvement. Research indicates the compound inhibits NNMT-mediated NAD+ depletion, enhances NAD+-dependent sirtuin signaling, and promotes metabolic adaptations similar to caloric restriction and exercise. 5-Amino-1MQ represents a valuable research tool for investigating NAD+ metabolism, NNMT inhibition, metabolic regulation, and therapeutic approaches to metabolic dysfunction and obesity.
Biochemical Characteristics
5-Amino-1MQ is a small molecule compound with molecular weight approximately 170 Da. The compound is a selective NNMT inhibitor designed to block the enzymatic conversion of nicotinamide to N-methylnicotinamide (MNA), preventing NAD+ depletion. The compound is water-soluble and demonstrates stability across physiological pH ranges (6.5–8.0). 5-Amino-1MQ exhibits excellent cell membrane penetration and bioavailability, efficiently distributing to tissues involved in metabolic regulation. Cellular uptake occurs through diffusion and transporter-mediated mechanisms. The compound localizes to cells expressing NNMT enzyme including adipocytes, hepatocytes, and muscle cells where metabolic effects are exerted.
Biochemical Characteristics
5-Amino-1MQ is a small molecule compound with molecular weight approximately 170 Da. The compound is a selective NNMT inhibitor designed to block the enzymatic conversion of nicotinamide to N-methylnicotinamide (MNA), preventing NAD+ depletion. The compound is water-soluble and demonstrates stability across physiological pH ranges (6.5–8.0). 5-Amino-1MQ exhibits excellent cell membrane penetration and bioavailability, efficiently distributing to tissues involved in metabolic regulation. Cellular uptake occurs through diffusion and transporter-mediated mechanisms. The compound localizes to cells expressing NNMT enzyme including adipocytes, hepatocytes, and muscle cells where metabolic effects are exerted.
Research Applications
NAD+ Enhancement Investigation of 5-Amino-1MQ-induced elevation of cellular NAD+ levels through NNMT inhibition. Metabolic Rate Enhancement Assessment of increased energy expenditure and metabolic rate through NAD+-dependent mechanisms. Body Weight Reduction Study of body weight loss and improved body composition through enhanced metabolic flexibility. Adipose Tissue Remodeling Investigation of browning of white adipose tissue and enhanced brown adipose tissue thermogenesis. Glucose Homeostasis Assessment of improvements in glucose tolerance and insulin sensitivity through metabolic enhancement. Mitochondrial Function Study of enhancement of mitochondrial oxidative capacity and ATP production efficiency. Sirtuin Activation Investigation of NAD+-dependent sirtuin pathway enhancement and activation of longevity pathways.
Research Applications
NAD+ Enhancement Investigation of 5-Amino-1MQ-induced elevation of cellular NAD+ levels through NNMT inhibition. Metabolic Rate Enhancement Assessment of increased energy expenditure and metabolic rate through NAD+-dependent mechanisms. Body Weight Reduction Study of body weight loss and improved body composition through enhanced metabolic flexibility. Adipose Tissue Remodeling Investigation of browning of white adipose tissue and enhanced brown adipose tissue thermogenesis. Glucose Homeostasis Assessment of improvements in glucose tolerance and insulin sensitivity through metabolic enhancement. Mitochondrial Function Study of enhancement of mitochondrial oxidative capacity and ATP production efficiency. Sirtuin Activation Investigation of NAD+-dependent sirtuin pathway enhancement and activation of longevity pathways.
Pathway / Mechanistic Context
NNMT Inhibition 5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT) enzyme, blocking the conversion of nicotinamide to N-methylnicotinamide (MNA) and preventing NAD+ depletion. NAD+ Elevation By inhibiting NNMT-mediated NAD+ consumption, 5-Amino-1MQ increases cellular NAD+ levels, providing enhanced substrate availability for NAD+-dependent enzymes including sirtuins and PARPs. Sirtuin Activation Enhanced NAD+ availability promotes activation of NAD+-dependent sirtuins (SIRT1-7), which enhance mitochondrial biogenesis, metabolic flexibility, and cellular stress resistance. Brown Adipose Tissue Activation The compound promotes conversion of white adipocytes to brown/beige adipocytes through activation of brown adipose tissue thermogenic pathways, increasing energy expenditure. Mitochondrial Biogenesis 5-Amino-1MQ-induced NAD+ elevation activates PGC-1α through sirtuin-dependent mechanisms, promoting mitochondrial biogenesis and enhanced oxidative capacity. Metabolic Switching Enhancement The compound enhances metabolic flexibility and ability to switch between glucose and lipid oxidation through activation of AMPK and other metabolic regulators dependent on NAD+ availability.
Pathway / Mechanistic Context
NNMT Inhibition 5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT) enzyme, blocking the conversion of nicotinamide to N-methylnicotinamide (MNA) and preventing NAD+ depletion. NAD+ Elevation By inhibiting NNMT-mediated NAD+ consumption, 5-Amino-1MQ increases cellular NAD+ levels, providing enhanced substrate availability for NAD+-dependent enzymes including sirtuins and PARPs. Sirtuin Activation Enhanced NAD+ availability promotes activation of NAD+-dependent sirtuins (SIRT1-7), which enhance mitochondrial biogenesis, metabolic flexibility, and cellular stress resistance. Brown Adipose Tissue Activation The compound promotes conversion of white adipocytes to brown/beige adipocytes through activation of brown adipose tissue thermogenic pathways, increasing energy expenditure. Mitochondrial Biogenesis 5-Amino-1MQ-induced NAD+ elevation activates PGC-1α through sirtuin-dependent mechanisms, promoting mitochondrial biogenesis and enhanced oxidative capacity. Metabolic Switching Enhancement The compound enhances metabolic flexibility and ability to switch between glucose and lipid oxidation through activation of AMPK and other metabolic regulators dependent on NAD+ availability.
Preclinical Research Summary
5-Amino-1MQ is supplied as pharmaceutical-grade powder at purities of ≥98%. Standard concentrations available in solution form at 5–50 mM. Storage at room temperature (15–30°C) in sealed containers; shelf-life typically 24–36 months. Analytical testing includes HPLC purity verification (≥98%), HPLC-MS molecular confirmation, elemental analysis, and chemical stability assessment. Bioassay verification of NNMT inhibitory activity available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
5-Amino-1MQ is supplied as pharmaceutical-grade powder at purities of ≥98%. Standard concentrations available in solution form at 5–50 mM. Storage at room temperature (15–30°C) in sealed containers; shelf-life typically 24–36 months. Analytical testing includes HPLC purity verification (≥98%), HPLC-MS molecular confirmation, elemental analysis, and chemical stability assessment. Bioassay verification of NNMT inhibitory activity available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.