This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
DSIP
$
139 AUD
Product Info
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide studied in laboratory research for its effects on sleep regulation, stress response, and neuroendocrine signalling. It is commonly used in controlled experimental settings to investigate cellular pathways related to circadian rhythm, neurotransmission, and peptide–receptor interactions. DSIP is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Categories
Bacteriostatic Water
AOD
Cagrilintide
Cagrilintide + Semaglutide
Retatrutide
Semaglutide
Tirzepatide
SLU PP 332
MOTS C
BPC 157
bpc-157-tb-500
Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
DSIP (delta sleep-inducing peptide) is a synthetic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from the cerebrospinal fluid of sleep-deprived animals. The peptide is a natural sleep factor that promotes sleep initiation and maintenance of deep sleep architecture. DSIP is extensively studied for its role in sleep regulation, circadian rhythm maintenance, and stress resilience. Research indicates the peptide enhances slow-wave sleep (SWS), improves sleep quality, and supports recovery from sleep deprivation through modulation of sleep-promoting neural circuits. DSIP represents a valuable research tool for investigating sleep neurobiology, circadian rhythms, and therapeutic approaches to sleep disorders and sleep-related dysfunction.
Overview
DSIP (delta sleep-inducing peptide) is a synthetic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from the cerebrospinal fluid of sleep-deprived animals. The peptide is a natural sleep factor that promotes sleep initiation and maintenance of deep sleep architecture. DSIP is extensively studied for its role in sleep regulation, circadian rhythm maintenance, and stress resilience. Research indicates the peptide enhances slow-wave sleep (SWS), improves sleep quality, and supports recovery from sleep deprivation through modulation of sleep-promoting neural circuits. DSIP represents a valuable research tool for investigating sleep neurobiology, circadian rhythms, and therapeutic approaches to sleep disorders and sleep-related dysfunction.
Biochemical Characteristics
DSIP is a 9-amino acid peptide with molecular weight of approximately 1,079 Da. The peptide contains both hydrophobic and charged amino acids enabling multiple interactions with sleep-regulating neural circuits. The peptide is water-soluble and crosses the blood-brain barrier efficiently, localizing to brain regions involved in sleep-wake regulation. DSIP demonstrates stability across physiological pH ranges (6.5–8.0) and shows moderate enzymatic resistance supporting biological activity. Cellular uptake occurs through receptor-mediated mechanisms and peptide transporter pathways. The peptide localizes to hypothalamus, basal forebrain, and brainstem sleep-promoting regions.
Biochemical Characteristics
DSIP is a 9-amino acid peptide with molecular weight of approximately 1,079 Da. The peptide contains both hydrophobic and charged amino acids enabling multiple interactions with sleep-regulating neural circuits. The peptide is water-soluble and crosses the blood-brain barrier efficiently, localizing to brain regions involved in sleep-wake regulation. DSIP demonstrates stability across physiological pH ranges (6.5–8.0) and shows moderate enzymatic resistance supporting biological activity. Cellular uptake occurs through receptor-mediated mechanisms and peptide transporter pathways. The peptide localizes to hypothalamus, basal forebrain, and brainstem sleep-promoting regions.
Research Applications
Sleep Initiation Investigation of DSIP-induced acceleration of sleep onset and reduction in sleep latency. Deep Sleep Enhancement Assessment of increased slow-wave sleep (SWS) quantity and quality in sleep models. Sleep Architecture Study of improvement in sleep stage distribution and restoration of normal sleep cycling patterns. Sleep Deprivation Recovery Investigation of accelerated recovery from sleep loss and restoration of cognitive performance. Circadian Rhythm Support Assessment of enhancement of circadian rhythm stability and sleep-wake cycle entrainment. Stress Resilience Study of DSIP-mediated reduction in stress-induced sleep disruption and anxiety. Cognitive & Memory Function Investigation of improvements in learning, memory consolidation, and cognitive performance through enhanced sleep quality.
Research Applications
Sleep Initiation Investigation of DSIP-induced acceleration of sleep onset and reduction in sleep latency. Deep Sleep Enhancement Assessment of increased slow-wave sleep (SWS) quantity and quality in sleep models. Sleep Architecture Study of improvement in sleep stage distribution and restoration of normal sleep cycling patterns. Sleep Deprivation Recovery Investigation of accelerated recovery from sleep loss and restoration of cognitive performance. Circadian Rhythm Support Assessment of enhancement of circadian rhythm stability and sleep-wake cycle entrainment. Stress Resilience Study of DSIP-mediated reduction in stress-induced sleep disruption and anxiety. Cognitive & Memory Function Investigation of improvements in learning, memory consolidation, and cognitive performance through enhanced sleep quality.
Pathway / Mechanistic Context
Sleep-Promoting Neural Circuits DSIP activates sleep-promoting neurons in the ventrolateral preoptic area (VLPO) and other sleep-active neural regions, enhancing GABAergic inhibition of wake-promoting arousal systems. GABA & Adenosine Enhancement The peptide enhances GABAergic neurotransmission and adenosine signaling in sleep-regulating circuits, promoting sleep onset and maintenance through inhibition of wake-promoting pathways. Slow-Wave Sleep Promotion DSIP specifically enhances slow-wave sleep (SWS) through activation of sleep spindle-generating circuits and deep sleep oscillatory activity in the thalamocortical system. Orexin/Hypocretin Suppression The peptide suppresses activity of wake-promoting orexin neurons in the lateral hypothalamus, reducing arousal signals and facilitating sleep maintenance. Circadian Regulation DSIP supports circadian rhythm regulation through modulation of suprachiasmatic nucleus (SCN) activity and melatonin signaling, promoting sleep-wake cycle entrainment. Stress-Sleep Integration The peptide reduces HPA axis hyperresponsiveness and cortisol-mediated sleep disruption, promoting sleep resilience under psychological and physiological stress.
Pathway / Mechanistic Context
Sleep-Promoting Neural Circuits DSIP activates sleep-promoting neurons in the ventrolateral preoptic area (VLPO) and other sleep-active neural regions, enhancing GABAergic inhibition of wake-promoting arousal systems. GABA & Adenosine Enhancement The peptide enhances GABAergic neurotransmission and adenosine signaling in sleep-regulating circuits, promoting sleep onset and maintenance through inhibition of wake-promoting pathways. Slow-Wave Sleep Promotion DSIP specifically enhances slow-wave sleep (SWS) through activation of sleep spindle-generating circuits and deep sleep oscillatory activity in the thalamocortical system. Orexin/Hypocretin Suppression The peptide suppresses activity of wake-promoting orexin neurons in the lateral hypothalamus, reducing arousal signals and facilitating sleep maintenance. Circadian Regulation DSIP supports circadian rhythm regulation through modulation of suprachiasmatic nucleus (SCN) activity and melatonin signaling, promoting sleep-wake cycle entrainment. Stress-Sleep Integration The peptide reduces HPA axis hyperresponsiveness and cortisol-mediated sleep disruption, promoting sleep resilience under psychological and physiological stress.
Preclinical Research Summary
DSIP is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of sleep-promoting activity available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
DSIP is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of sleep-promoting activity available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.