This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
SERMORELIN
$
99.99 AUD
Product Info
Sermorelin is a synthetic peptide analogue of growth hormone-releasing hormone (GHRH) used in laboratory research to study growth hormone secretion and endocrine signalling pathways. It is commonly utilised in controlled experimental settings focused on hormone regulation, receptor interaction, and peptide-based signalling mechanisms. Sermorelin is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Sermorelin is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring growth hormone-releasing hormone (GHRH 1-29). The peptide is a GHRH analog designed to enhance endogenous growth hormone secretion from the pituitary gland. Sermorelin is extensively studied for its potential in supporting growth hormone production, metabolic function, and age-related decline in somatotropin secretion. Research indicates the peptide stimulates GH release through GHRH receptor activation, promoting improvements in body composition, metabolic rate, and physical performance. Sermorelin represents a valuable research tool for investigating growth hormone physiology, metabolic adaptation, and therapeutic approaches to age-related growth hormone decline and GH deficiency.
Overview
Sermorelin is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring growth hormone-releasing hormone (GHRH 1-29). The peptide is a GHRH analog designed to enhance endogenous growth hormone secretion from the pituitary gland. Sermorelin is extensively studied for its potential in supporting growth hormone production, metabolic function, and age-related decline in somatotropin secretion. Research indicates the peptide stimulates GH release through GHRH receptor activation, promoting improvements in body composition, metabolic rate, and physical performance. Sermorelin represents a valuable research tool for investigating growth hormone physiology, metabolic adaptation, and therapeutic approaches to age-related growth hormone decline and GH deficiency.
Biochemical Characteristics
Sermorelin is a 29-amino acid peptide with molecular weight of approximately 3,357 Da. The peptide consists of the complete active N-terminal region of human GHRH responsible for receptor binding and biological activity. The peptide is water-soluble and demonstrates stability across physiological pH ranges (6.5–8.0). Sermorelin exhibits shorter biological half-life compared to longer-acting GHRH analogs due to limited enzymatic protection, typically requiring more frequent dosing for sustained GH stimulation. Cellular uptake occurs through GHRH receptor binding and internalization on anterior pituitary somatotroph cells. The peptide localizes to hypothalamic and pituitary tissue where growth hormone regulation occurs.
Biochemical Characteristics
Sermorelin is a 29-amino acid peptide with molecular weight of approximately 3,357 Da. The peptide consists of the complete active N-terminal region of human GHRH responsible for receptor binding and biological activity. The peptide is water-soluble and demonstrates stability across physiological pH ranges (6.5–8.0). Sermorelin exhibits shorter biological half-life compared to longer-acting GHRH analogs due to limited enzymatic protection, typically requiring more frequent dosing for sustained GH stimulation. Cellular uptake occurs through GHRH receptor binding and internalization on anterior pituitary somatotroph cells. The peptide localizes to hypothalamic and pituitary tissue where growth hormone regulation occurs.
Research Applications
Growth Hormone Stimulation Investigation of sermorelin-induced enhancement of endogenous growth hormone release and secretory patterns. Lean Mass Development Assessment of GH-dependent increase in muscle protein synthesis and lean body mass accumulation. Metabolic Rate Enhancement Study of improvements in metabolic rate, energy expenditure, and metabolic flexibility. Body Composition Improvement Investigation of improvements in lean-to-fat mass ratio and reduction in abdominal adiposity. Age-Related GH Decline Assessment of restoration of GH secretion in aging and potential benefits in age-related somatopause. Physical Performance Study of improvements in strength, power output, and exercise capacity through GH enhancement. Bone Density Support Investigation of support for bone remodeling and improvement in bone mineral density through GH signaling.
Research Applications
Growth Hormone Stimulation Investigation of sermorelin-induced enhancement of endogenous growth hormone release and secretory patterns. Lean Mass Development Assessment of GH-dependent increase in muscle protein synthesis and lean body mass accumulation. Metabolic Rate Enhancement Study of improvements in metabolic rate, energy expenditure, and metabolic flexibility. Body Composition Improvement Investigation of improvements in lean-to-fat mass ratio and reduction in abdominal adiposity. Age-Related GH Decline Assessment of restoration of GH secretion in aging and potential benefits in age-related somatopause. Physical Performance Study of improvements in strength, power output, and exercise capacity through GH enhancement. Bone Density Support Investigation of support for bone remodeling and improvement in bone mineral density through GH signaling.
Pathway / Mechanistic Context
GHRH Receptor Activation Sermorelin activates growth hormone-releasing hormone (GHRH) receptors on anterior pituitary somatotroph cells, triggering cAMP-dependent signaling that enhances growth hormone synthesis and secretion. Growth Hormone Release GHRH receptor activation promotes accumulation of GH in secretory granules and triggers pulsatile exocytosis, resulting in robust growth hormone release into systemic circulation. IGF-1 Production Growth hormone released through sermorelin stimulation acts on hepatic and peripheral tissues to enhance insulin-like growth factor-1 (IGF-1) production, mediating many metabolic and anabolic effects. Lipolysis & Fat Mobilization GH released through sermorelin stimulation enhances lipolysis in adipose tissue through hormone-sensitive lipase activation, promoting fat mobilization and oxidation. Protein Synthesis Enhancement GH and IGF-1 promote muscle protein synthesis through mTOR pathway activation and myogenic gene expression, supporting lean mass accumulation. Somatostatin Feedback Regulation Sermorelin-induced GH release provides negative feedback that modulates somatostatin (GHIH) secretion, maintaining homeostatic control of GH axis function.
Pathway / Mechanistic Context
GHRH Receptor Activation Sermorelin activates growth hormone-releasing hormone (GHRH) receptors on anterior pituitary somatotroph cells, triggering cAMP-dependent signaling that enhances growth hormone synthesis and secretion. Growth Hormone Release GHRH receptor activation promotes accumulation of GH in secretory granules and triggers pulsatile exocytosis, resulting in robust growth hormone release into systemic circulation. IGF-1 Production Growth hormone released through sermorelin stimulation acts on hepatic and peripheral tissues to enhance insulin-like growth factor-1 (IGF-1) production, mediating many metabolic and anabolic effects. Lipolysis & Fat Mobilization GH released through sermorelin stimulation enhances lipolysis in adipose tissue through hormone-sensitive lipase activation, promoting fat mobilization and oxidation. Protein Synthesis Enhancement GH and IGF-1 promote muscle protein synthesis through mTOR pathway activation and myogenic gene expression, supporting lean mass accumulation. Somatostatin Feedback Regulation Sermorelin-induced GH release provides negative feedback that modulates somatostatin (GHIH) secretion, maintaining homeostatic control of GH axis function.
Preclinical Research Summary
Sermorelin is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of GHRH receptor agonist activity and GH-stimulatory effects available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
Sermorelin is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of GHRH receptor agonist activity and GH-stimulatory effects available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.