SLU-PP-332 - My Framer Site

Overview

SLU-PP-332 is a synthetic peptide developed as a neuroprotective and neuroregenerative agent targeting central and peripheral nervous system dysfunction. The peptide is designed to modulate neuroinflammatory pathways and support neural cell survival and plasticity. SLU-PP-332 is studied for its potential in supporting neuroprotection, enhancing neural regeneration, and promoting recovery from neurological injury. Research indicates the peptide suppresses neuroinflammatory cytokine production, promotes neurotrophic factor signaling, and supports neuronal survival through multiple coordinated mechanisms. SLU-PP-332 represents a valuable research tool for investigating neuroprotective mechanisms, neuroinflammation modulation, and therapeutic approaches to neurological diseases and neural injury.

Overview

SLU-PP-332 is a synthetic peptide developed as a neuroprotective and neuroregenerative agent targeting central and peripheral nervous system dysfunction. The peptide is designed to modulate neuroinflammatory pathways and support neural cell survival and plasticity. SLU-PP-332 is studied for its potential in supporting neuroprotection, enhancing neural regeneration, and promoting recovery from neurological injury. Research indicates the peptide suppresses neuroinflammatory cytokine production, promotes neurotrophic factor signaling, and supports neuronal survival through multiple coordinated mechanisms. SLU-PP-332 represents a valuable research tool for investigating neuroprotective mechanisms, neuroinflammation modulation, and therapeutic approaches to neurological diseases and neural injury.

Overview

SLU-PP-332 is a synthetic peptide developed as a neuroprotective and neuroregenerative agent targeting central and peripheral nervous system dysfunction. The peptide is designed to modulate neuroinflammatory pathways and support neural cell survival and plasticity. SLU-PP-332 is studied for its potential in supporting neuroprotection, enhancing neural regeneration, and promoting recovery from neurological injury. Research indicates the peptide suppresses neuroinflammatory cytokine production, promotes neurotrophic factor signaling, and supports neuronal survival through multiple coordinated mechanisms. SLU-PP-332 represents a valuable research tool for investigating neuroprotective mechanisms, neuroinflammation modulation, and therapeutic approaches to neurological diseases and neural injury.

Biochemical Characteristics

SLU-PP-332 is a synthetic peptide with molecular weight designed for optimal central nervous system penetration and bioavailability. The peptide structure enables multiple receptor interactions within neural tissue and neuroinflammatory cell populations. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). SLU-PP-332 crosses the blood-brain barrier efficiently and localizes to central nervous system tissues. The peptide exhibits resistance to enzymatic degradation, supporting extended biological activity. Cellular uptake occurs through receptor-mediated mechanisms and peptide transporter pathways. The peptide localizes to neurons, glia, and neuroinflammatory cells where neuroprotective effects are exerted.

Biochemical Characteristics

SLU-PP-332 is a synthetic peptide with molecular weight designed for optimal central nervous system penetration and bioavailability. The peptide structure enables multiple receptor interactions within neural tissue and neuroinflammatory cell populations. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). SLU-PP-332 crosses the blood-brain barrier efficiently and localizes to central nervous system tissues. The peptide exhibits resistance to enzymatic degradation, supporting extended biological activity. Cellular uptake occurs through receptor-mediated mechanisms and peptide transporter pathways. The peptide localizes to neurons, glia, and neuroinflammatory cells where neuroprotective effects are exerted.

Biochemical Characteristics

SLU-PP-332 is a synthetic peptide with molecular weight designed for optimal central nervous system penetration and bioavailability. The peptide structure enables multiple receptor interactions within neural tissue and neuroinflammatory cell populations. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). SLU-PP-332 crosses the blood-brain barrier efficiently and localizes to central nervous system tissues. The peptide exhibits resistance to enzymatic degradation, supporting extended biological activity. Cellular uptake occurs through receptor-mediated mechanisms and peptide transporter pathways. The peptide localizes to neurons, glia, and neuroinflammatory cells where neuroprotective effects are exerted.

Research Applications

Neuroprotection Investigation of SLU-PP-332-induced protection against neuronal injury and excitotoxic damage. Neuroinflammation Modulation Assessment of suppression of pro-inflammatory cytokine production and microglial activation. Neural Regeneration Study of enhancement of axonal regeneration and neuroplasticity in injured neural tissue. Neurodegenerative Disease Models Investigation of potential benefit in Parkinson's disease, Alzheimer's disease, and ALS models. Spinal Cord Injury Recovery Assessment of neuroprotection and functional recovery in spinal cord injury models. Peripheral Nerve Repair Study of enhancement of peripheral nerve regeneration and functional recovery following nerve injury. Glial Cell Function Investigation of modulation of astrocyte and oligodendrocyte function supporting neural support and myelin integrity.

Research Applications

Neuroprotection Investigation of SLU-PP-332-induced protection against neuronal injury and excitotoxic damage. Neuroinflammation Modulation Assessment of suppression of pro-inflammatory cytokine production and microglial activation. Neural Regeneration Study of enhancement of axonal regeneration and neuroplasticity in injured neural tissue. Neurodegenerative Disease Models Investigation of potential benefit in Parkinson's disease, Alzheimer's disease, and ALS models. Spinal Cord Injury Recovery Assessment of neuroprotection and functional recovery in spinal cord injury models. Peripheral Nerve Repair Study of enhancement of peripheral nerve regeneration and functional recovery following nerve injury. Glial Cell Function Investigation of modulation of astrocyte and oligodendrocyte function supporting neural support and myelin integrity.

Research Applications

Neuroprotection Investigation of SLU-PP-332-induced protection against neuronal injury and excitotoxic damage. Neuroinflammation Modulation Assessment of suppression of pro-inflammatory cytokine production and microglial activation. Neural Regeneration Study of enhancement of axonal regeneration and neuroplasticity in injured neural tissue. Neurodegenerative Disease Models Investigation of potential benefit in Parkinson's disease, Alzheimer's disease, and ALS models. Spinal Cord Injury Recovery Assessment of neuroprotection and functional recovery in spinal cord injury models. Peripheral Nerve Repair Study of enhancement of peripheral nerve regeneration and functional recovery following nerve injury. Glial Cell Function Investigation of modulation of astrocyte and oligodendrocyte function supporting neural support and myelin integrity.

Pathway / Mechanistic Context

Microglial Suppression SLU-PP-332 suppresses activation of microglial cells and reduces production of pro-inflammatory mediators including TNF-α, IL-6, and IL-1β through modulation of NF-κB and MAPK signaling pathways. Neuroprotective Cytokine Production The peptide enhances production of anti-inflammatory IL-10 and TGF-β, promoting neuroprotective immune responses and repair-promoting inflammatory microenvironment. Neurotrophic Factor Signaling SLU-PP-332 enhances brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) signaling, supporting neuronal survival, differentiation, and axonal growth. Oxidative Stress Reduction The peptide enhances antioxidant defense enzyme expression including superoxide dismutase and catalase, reducing reactive oxygen species accumulation in neural tissue. Astrocyte Activation & Support SLU-PP-332 promotes astrocyte activation toward neuroprotective phenotype supporting neuronal metabolism and providing trophic support. Neuroplasticity Enhancement The peptide promotes long-term potentiation (LTP) and synaptic plasticity through enhancement of NMDA receptor signaling and dendritic growth.

Pathway / Mechanistic Context

Microglial Suppression SLU-PP-332 suppresses activation of microglial cells and reduces production of pro-inflammatory mediators including TNF-α, IL-6, and IL-1β through modulation of NF-κB and MAPK signaling pathways. Neuroprotective Cytokine Production The peptide enhances production of anti-inflammatory IL-10 and TGF-β, promoting neuroprotective immune responses and repair-promoting inflammatory microenvironment. Neurotrophic Factor Signaling SLU-PP-332 enhances brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) signaling, supporting neuronal survival, differentiation, and axonal growth. Oxidative Stress Reduction The peptide enhances antioxidant defense enzyme expression including superoxide dismutase and catalase, reducing reactive oxygen species accumulation in neural tissue. Astrocyte Activation & Support SLU-PP-332 promotes astrocyte activation toward neuroprotective phenotype supporting neuronal metabolism and providing trophic support. Neuroplasticity Enhancement The peptide promotes long-term potentiation (LTP) and synaptic plasticity through enhancement of NMDA receptor signaling and dendritic growth.

Pathway / Mechanistic Context

Microglial Suppression SLU-PP-332 suppresses activation of microglial cells and reduces production of pro-inflammatory mediators including TNF-α, IL-6, and IL-1β through modulation of NF-κB and MAPK signaling pathways. Neuroprotective Cytokine Production The peptide enhances production of anti-inflammatory IL-10 and TGF-β, promoting neuroprotective immune responses and repair-promoting inflammatory microenvironment. Neurotrophic Factor Signaling SLU-PP-332 enhances brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) signaling, supporting neuronal survival, differentiation, and axonal growth. Oxidative Stress Reduction The peptide enhances antioxidant defense enzyme expression including superoxide dismutase and catalase, reducing reactive oxygen species accumulation in neural tissue. Astrocyte Activation & Support SLU-PP-332 promotes astrocyte activation toward neuroprotective phenotype supporting neuronal metabolism and providing trophic support. Neuroplasticity Enhancement The peptide promotes long-term potentiation (LTP) and synaptic plasticity through enhancement of NMDA receptor signaling and dendritic growth.

Preclinical Research Summary

SLU-PP-332 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of neuroprotective activity available upon request. Certificate of Analysis provided with each lot.

Preclinical Research Summary

SLU-PP-332 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of neuroprotective activity available upon request. Certificate of Analysis provided with each lot.

Preclinical Research Summary

SLU-PP-332 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of neuroprotective activity available upon request. Certificate of Analysis provided with each lot.

RUO Disclaimer

RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.

RUO Disclaimer

RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.

RUO Disclaimer

RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.