IPAMORELIN
$
179 AUD
Product Info
Ipamorelin is a synthetic pentapeptide used in laboratory research to study growth hormone release and ghrelin receptor activity. It is commonly examined in controlled experimental settings focused on endocrine signalling, peptide–receptor interactions, and hormonal regulation pathways. Ipamorelin is of interest for its selective receptor activity, making it useful in research models exploring growth hormone dynamics. This compound is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Ipamorelin is a synthetic pentapeptide (Aib-His-D2Nal-D-Phe-Lys-NH2) ghrelin mimetic designed to selectively activate growth hormone secretagogue receptors (GHS-R) on anterior pituitary somatotroph cells. The peptide stimulates endogenous growth hormone secretion with high selectivity and minimal off-target effects. Ipamorelin is extensively studied for its potential in supporting growth hormone production, lean mass development, and metabolic health. Research indicates the peptide stimulates GH release through ghrelin receptor activation while showing remarkable selectivity for GH secretion over cortisol and prolactin release. Ipamorelin represents a valuable research tool for investigating growth hormone physiology, ghrelin signaling, and therapeutic approaches to GH deficiency and age-related metabolic decline.
Overview
Ipamorelin is a synthetic pentapeptide (Aib-His-D2Nal-D-Phe-Lys-NH2) ghrelin mimetic designed to selectively activate growth hormone secretagogue receptors (GHS-R) on anterior pituitary somatotroph cells. The peptide stimulates endogenous growth hormone secretion with high selectivity and minimal off-target effects. Ipamorelin is extensively studied for its potential in supporting growth hormone production, lean mass development, and metabolic health. Research indicates the peptide stimulates GH release through ghrelin receptor activation while showing remarkable selectivity for GH secretion over cortisol and prolactin release. Ipamorelin represents a valuable research tool for investigating growth hormone physiology, ghrelin signaling, and therapeutic approaches to GH deficiency and age-related metabolic decline.
Biochemical Characteristics
Ipamorelin is a 5-amino acid cyclic peptide with molecular weight of approximately 711 Da. The peptide contains non-natural amino acids including D-amino acids and alanine isobutyrate (Aib), providing enhanced receptor selectivity and metabolic stability. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). Ipamorelin exhibits extended biological half-life due to resistance to enzymatic degradation and high binding affinity for ghrelin receptors. Cellular uptake occurs through growth hormone secretagogue receptor (GHS-R) binding and internalization on pituitary somatotroph cells. The peptide localizes to anterior pituitary tissue where growth hormone regulation occurs.
Biochemical Characteristics
Ipamorelin is a 5-amino acid cyclic peptide with molecular weight of approximately 711 Da. The peptide contains non-natural amino acids including D-amino acids and alanine isobutyrate (Aib), providing enhanced receptor selectivity and metabolic stability. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). Ipamorelin exhibits extended biological half-life due to resistance to enzymatic degradation and high binding affinity for ghrelin receptors. Cellular uptake occurs through growth hormone secretagogue receptor (GHS-R) binding and internalization on pituitary somatotroph cells. The peptide localizes to anterior pituitary tissue where growth hormone regulation occurs.
Research Applications
Growth Hormone Stimulation Investigation of ipamorelin-induced enhancement of endogenous growth hormone release and pulsatile secretion patterns. Lean Mass Development Assessment of GH-dependent increase in muscle protein synthesis and lean body mass accumulation. Metabolic Rate Enhancement Study of improvements in metabolic rate, energy expenditure, and metabolic flexibility. Body Composition Improvement Investigation of improvements in lean-to-fat mass ratio and reduction in adiposity. Age-Related GH Decline Assessment of restoration of GH secretion in aging models and potential benefits in age-related somatopause. Physical Performance Study of improvements in strength, power output, and exercise capacity through GH enhancement. Bone Density Support Investigation of support for bone remodeling and improvement in bone mineral density.
Research Applications
Growth Hormone Stimulation Investigation of ipamorelin-induced enhancement of endogenous growth hormone release and pulsatile secretion patterns. Lean Mass Development Assessment of GH-dependent increase in muscle protein synthesis and lean body mass accumulation. Metabolic Rate Enhancement Study of improvements in metabolic rate, energy expenditure, and metabolic flexibility. Body Composition Improvement Investigation of improvements in lean-to-fat mass ratio and reduction in adiposity. Age-Related GH Decline Assessment of restoration of GH secretion in aging models and potential benefits in age-related somatopause. Physical Performance Study of improvements in strength, power output, and exercise capacity through GH enhancement. Bone Density Support Investigation of support for bone remodeling and improvement in bone mineral density.
Pathway / Mechanistic Context
Ghrelin Receptor Activation Ipamorelin activates growth hormone secretagogue receptors (GHS-R) on anterior pituitary somatotroph cells, triggering calcium-dependent signaling cascades that enhance growth hormone synthesis and secretion. Growth Hormone Release GHS-R activation promotes GH synthesis in somatotroph cells and triggers pulsatile exocytosis of growth hormone into systemic circulation with characteristic pulsatile secretion pattern. Hypothalamic Ghrelin Integration Ipamorelin engages both direct pituitary GHS-R activation and hypothalamic ghrelin signaling pathways, promoting GH-releasing hormone (GHRH) secretion for enhanced GH axis stimulation. Selective GH Secretion The peptide demonstrates remarkable selectivity for GH secretion over cortisol, prolactin, and ACTH release, minimizing off-target endocrine effects compared to non-selective secretagogues. IGF-1 Production Enhancement Growth hormone released through ipamorelin stimulation acts on hepatic and peripheral tissues to enhance insulin-like growth factor-1 production, mediating metabolic and anabolic effects. Somatostatin Suppression Ipamorelin-induced GH release provides feedback suppression of somatostatin (growth hormone-inhibiting hormone) secretion, supporting sustained GH axis responsiveness.
Pathway / Mechanistic Context
Ghrelin Receptor Activation Ipamorelin activates growth hormone secretagogue receptors (GHS-R) on anterior pituitary somatotroph cells, triggering calcium-dependent signaling cascades that enhance growth hormone synthesis and secretion. Growth Hormone Release GHS-R activation promotes GH synthesis in somatotroph cells and triggers pulsatile exocytosis of growth hormone into systemic circulation with characteristic pulsatile secretion pattern. Hypothalamic Ghrelin Integration Ipamorelin engages both direct pituitary GHS-R activation and hypothalamic ghrelin signaling pathways, promoting GH-releasing hormone (GHRH) secretion for enhanced GH axis stimulation. Selective GH Secretion The peptide demonstrates remarkable selectivity for GH secretion over cortisol, prolactin, and ACTH release, minimizing off-target endocrine effects compared to non-selective secretagogues. IGF-1 Production Enhancement Growth hormone released through ipamorelin stimulation acts on hepatic and peripheral tissues to enhance insulin-like growth factor-1 production, mediating metabolic and anabolic effects. Somatostatin Suppression Ipamorelin-induced GH release provides feedback suppression of somatostatin (growth hormone-inhibiting hormone) secretion, supporting sustained GH axis responsiveness.
Preclinical Research Summary
Ipamorelin is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation with D-amino acid verification, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of GHS-R agonist activity and GH-stimulatory effects available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
Ipamorelin is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation with D-amino acid verification, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of GHS-R agonist activity and GH-stimulatory effects available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.