SS-31
$
189 AUD
Product Info
SS-31 (Elamipretide) is a synthetic mitochondria-targeting tetrapeptide commonly used in laboratory research to study mitochondrial function, oxidative stress, and cellular bioenergetics. It is of interest in controlled experimental settings examining cardiolipin interactions, electron transport chain stabilisation, and mitochondrial membrane dynamics. SS-31 is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
SS-31 (elamipretide) is a tetrapeptide (Ala-Asp-Leu-Tyr) conjugated to a dimethyl tyrosine moiety, designed specifically to target and protect mitochondria. The peptide crosses the blood-brain barrier and localizes to the inner mitochondrial membrane where it exerts cytoprotective effects. SS-31 is extensively studied for its potential in preserving mitochondrial function, reducing oxidative stress, and protecting against age-related mitochondrial dysfunction. Research indicates the peptide prevents mitochondrial cristae destabilization and enhances energy production efficiency. SS-31 represents a valuable research tool for investigating mitochondrial biology, aging mechanisms, and therapeutic approaches to mitochondrial dysfunction and age-related diseases.
Overview
SS-31 (elamipretide) is a tetrapeptide (Ala-Asp-Leu-Tyr) conjugated to a dimethyl tyrosine moiety, designed specifically to target and protect mitochondria. The peptide crosses the blood-brain barrier and localizes to the inner mitochondrial membrane where it exerts cytoprotective effects. SS-31 is extensively studied for its potential in preserving mitochondrial function, reducing oxidative stress, and protecting against age-related mitochondrial dysfunction. Research indicates the peptide prevents mitochondrial cristae destabilization and enhances energy production efficiency. SS-31 represents a valuable research tool for investigating mitochondrial biology, aging mechanisms, and therapeutic approaches to mitochondrial dysfunction and age-related diseases.
Biochemical Characteristics
SS-31 is a 4-amino acid peptide conjugated to dimethyl tyrosine with molecular weight of approximately 623 Da. The peptide structure enables selective mitochondrial targeting and inner membrane localization. The peptide is water-soluble and demonstrates excellent cell membrane penetration and mitochondrial matrix accumulation. The dimethyl tyrosine conjugation provides increased lipophilicity enabling mitochondrial membrane crossing. SS-31 exhibits resistance to enzymatic degradation and maintains biological activity for extended periods in cells and tissues. The peptide localizes preferentially to the inner mitochondrial membrane and cristae where cardiolipin is enriched, enabling direct protective interactions with mitochondrial phospholipids.
Biochemical Characteristics
SS-31 is a 4-amino acid peptide conjugated to dimethyl tyrosine with molecular weight of approximately 623 Da. The peptide structure enables selective mitochondrial targeting and inner membrane localization. The peptide is water-soluble and demonstrates excellent cell membrane penetration and mitochondrial matrix accumulation. The dimethyl tyrosine conjugation provides increased lipophilicity enabling mitochondrial membrane crossing. SS-31 exhibits resistance to enzymatic degradation and maintains biological activity for extended periods in cells and tissues. The peptide localizes preferentially to the inner mitochondrial membrane and cristae where cardiolipin is enriched, enabling direct protective interactions with mitochondrial phospholipids.
Research Applications
Mitochondrial Oxidative Stress Investigation of SS-31-induced reduction in reactive oxygen species (ROS) production and oxidative damage in mitochondria. Energy Metabolism Assessment of enhancement of mitochondrial ATP production efficiency and metabolic capacity. Mitochondrial Dysfunction Models Study of protective effects in age-related mitochondrial dysfunction and metabolic decline. Neurodegenerative Disease Models Examination of neuroprotection in Parkinson's disease, Alzheimer's disease, and other mitochondrial-dysfunction-related conditions. Cardiovascular Health Investigation of cardioprotection in ischemia-reperfusion injury and age-related cardiac dysfunction. Aging & Senescence Assessment of SS-31 effects on cellular aging, senescent cell behavior, and age-related metabolic decline. Cell Survival & Apoptosis Study of enhancement of cell survival and prevention of mitochondrial-dependent apoptotic pathways.
Research Applications
Mitochondrial Oxidative Stress Investigation of SS-31-induced reduction in reactive oxygen species (ROS) production and oxidative damage in mitochondria. Energy Metabolism Assessment of enhancement of mitochondrial ATP production efficiency and metabolic capacity. Mitochondrial Dysfunction Models Study of protective effects in age-related mitochondrial dysfunction and metabolic decline. Neurodegenerative Disease Models Examination of neuroprotection in Parkinson's disease, Alzheimer's disease, and other mitochondrial-dysfunction-related conditions. Cardiovascular Health Investigation of cardioprotection in ischemia-reperfusion injury and age-related cardiac dysfunction. Aging & Senescence Assessment of SS-31 effects on cellular aging, senescent cell behavior, and age-related metabolic decline. Cell Survival & Apoptosis Study of enhancement of cell survival and prevention of mitochondrial-dependent apoptotic pathways.
Pathway / Mechanistic Context
Mitochondrial Localization SS-31 crosses cell membranes and selectively accumulates in mitochondria, particularly localizing to the inner membrane where cardiolipin is enriched. Cardiolipin Interaction The peptide binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae organization and preventing aberrant remodeling associated with apoptosis and dysfunction. ROS Reduction SS-31 suppresses peroxidase activity of cytochrome c bound to cardiolipin, reducing hydrogen peroxide production and mitochondrial ROS generation at the site of origin. Electron Transport Chain Preservation The peptide maintains optimal organization of electron transport chain protein complexes, enhancing oxidative phosphorylation efficiency and reducing electron leakage. Apoptosis Prevention SS-31 prevents mitochondrial cristae remodeling and cytochrome c release, blocking activation of caspase-mediated apoptosis pathways. Mitochondrial Biogenesis Support The peptide supports preservation of mitochondrial membrane potential and ATP production, promoting mitochondrial quality maintenance and selective autophagy of dysfunctional organelles.
Pathway / Mechanistic Context
Mitochondrial Localization SS-31 crosses cell membranes and selectively accumulates in mitochondria, particularly localizing to the inner membrane where cardiolipin is enriched. Cardiolipin Interaction The peptide binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae organization and preventing aberrant remodeling associated with apoptosis and dysfunction. ROS Reduction SS-31 suppresses peroxidase activity of cytochrome c bound to cardiolipin, reducing hydrogen peroxide production and mitochondrial ROS generation at the site of origin. Electron Transport Chain Preservation The peptide maintains optimal organization of electron transport chain protein complexes, enhancing oxidative phosphorylation efficiency and reducing electron leakage. Apoptosis Prevention SS-31 prevents mitochondrial cristae remodeling and cytochrome c release, blocking activation of caspase-mediated apoptosis pathways. Mitochondrial Biogenesis Support The peptide supports preservation of mitochondrial membrane potential and ATP production, promoting mitochondrial quality maintenance and selective autophagy of dysfunctional organelles.
Preclinical Research Summary
SS-31 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Certificate of Analysis provided with each lot.
Preclinical Research Summary
SS-31 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.