This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
KLOW
$
339 AUD
Product Info
KLOW is a synthetic peptide compound commonly used in laboratory research to study metabolic regulation, adipose tissue function, and energy homeostasis pathways. It is of interest in controlled experimental settings examining lipid metabolism, cellular signaling cascades, and peptide effects on metabolic processes. KLOW is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
KLOW is a synthetic tetrapeptide composed of lysine-leucine-ornithine-tryptophan (K-L-O-W) designed to modulate growth hormone secretion and support anabolic processes. The peptide targets hypothalamic and pituitary signaling to enhance endogenous growth hormone production. KLOW is studied for its potential in muscle growth, recovery enhancement, and metabolic support. Research indicates the peptide influences somatotropin release and may support improvements in body composition and physical performance.
Overview
KLOW is a synthetic tetrapeptide composed of lysine-leucine-ornithine-tryptophan (K-L-O-W) designed to modulate growth hormone secretion and support anabolic processes. The peptide targets hypothalamic and pituitary signaling to enhance endogenous growth hormone production. KLOW is studied for its potential in muscle growth, recovery enhancement, and metabolic support. Research indicates the peptide influences somatotropin release and may support improvements in body composition and physical performance.
Biochemical Characteristics
KLOW is a tetrapeptide with molecular weight approximately 520 Da, composed of lysine (basic amino acid), leucine (branched-chain amino acid), ornithine (semi-essential amino acid), and tryptophan (aromatic amino acid). The specific amino acid composition enables multiple receptor interactions within the hypothalamic-pituitary axis. The peptide is water-soluble and stable across physiological pH ranges. Cellular uptake occurs through peptide transporter mechanisms and non-specific endocytosis. KLOW exhibits resistance to rapid enzymatic degradation in circulation, supporting extended biological half-life compared to shorter peptides.
Biochemical Characteristics
KLOW is a tetrapeptide with molecular weight approximately 520 Da, composed of lysine (basic amino acid), leucine (branched-chain amino acid), ornithine (semi-essential amino acid), and tryptophan (aromatic amino acid). The specific amino acid composition enables multiple receptor interactions within the hypothalamic-pituitary axis. The peptide is water-soluble and stable across physiological pH ranges. Cellular uptake occurs through peptide transporter mechanisms and non-specific endocytosis. KLOW exhibits resistance to rapid enzymatic degradation in circulation, supporting extended biological half-life compared to shorter peptides.
Research Applications
Growth Hormone Secretion Investigation of KLOW-induced enhancement of endogenous growth hormone release from somatotroph cells. Muscle Growth & Hypertrophy Assessment of anabolic effects on skeletal muscle development and protein synthesis. Body Composition Study of favorable shifts in lean mass and fat mass ratios in experimental models. Metabolic Support Investigation of enhanced metabolic rate and substrate utilization patterns. Recovery Enhancement Evaluation of improved physical recovery and reduced muscle damage markers post-exercise. Aging & Sarcopenia Examination of potential benefits in age-related muscle loss and functional decline.
Research Applications
Growth Hormone Secretion Investigation of KLOW-induced enhancement of endogenous growth hormone release from somatotroph cells. Muscle Growth & Hypertrophy Assessment of anabolic effects on skeletal muscle development and protein synthesis. Body Composition Study of favorable shifts in lean mass and fat mass ratios in experimental models. Metabolic Support Investigation of enhanced metabolic rate and substrate utilization patterns. Recovery Enhancement Evaluation of improved physical recovery and reduced muscle damage markers post-exercise. Aging & Sarcopenia Examination of potential benefits in age-related muscle loss and functional decline.
Pathway / Mechanistic Context
GHRH Receptor Signaling KLOW is proposed to activate growth hormone-releasing hormone (GHRH) receptor pathways on somatotroph cells, promoting cAMP-dependent growth hormone synthesis and secretion. Amino Acid Sensing The branched-chain leucine component engages nutrient-sensing pathways (mTOR) that synergize with GHRH signaling for enhanced GH secretion. Somatostatin Inhibition KLOW may modulate somatostatin tone through action on hypothalamic neurons, reducing inhibitory feedback on growth hormone release. Metabolic Signaling Ornithine and tryptophan activate metabolic pathways supporting anabolic states and enhanced protein synthesis in target tissues. Receptor-Mediated Uptake Peptide uptake into pituitary tissue occurs through peptide transporter proteins, enabling local bioavailability.
Pathway / Mechanistic Context
GHRH Receptor Signaling KLOW is proposed to activate growth hormone-releasing hormone (GHRH) receptor pathways on somatotroph cells, promoting cAMP-dependent growth hormone synthesis and secretion. Amino Acid Sensing The branched-chain leucine component engages nutrient-sensing pathways (mTOR) that synergize with GHRH signaling for enhanced GH secretion. Somatostatin Inhibition KLOW may modulate somatostatin tone through action on hypothalamic neurons, reducing inhibitory feedback on growth hormone release. Metabolic Signaling Ornithine and tryptophan activate metabolic pathways supporting anabolic states and enhanced protein synthesis in target tissues. Receptor-Mediated Uptake Peptide uptake into pituitary tissue occurs through peptide transporter proteins, enabling local bioavailability.
Preclinical Research Summary
KLOW is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–5 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Certificate of Analysis provided with each lot.
Preclinical Research Summary
KLOW is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–5 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.