THYMOSIN ALPHA-1
$
129 AUD
Product Info
Thymosin Alpha-1 is a synthetic peptide analogue of a thymic hormone fragment commonly used in laboratory research to study immune system modulation, T-cell differentiation, and immunoregulatory pathways. It is of interest in controlled experimental settings examining immune response mechanisms, cytokine signaling, and host defense systems. Thymosin Alpha-1 is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Thymosin alpha-1 is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue. The peptide is a key immunoregulatory factor that enhances T cell development, maturation, and immune function. Thymosin alpha-1 is extensively studied for its potential in supporting immune competence, enhancing resistance to infections, and modulating immune responses in aging and immunocompromised states. Research indicates the peptide promotes T cell development in the thymus and enhances peripheral T cell function. Thymosin alpha-1 represents a valuable research tool for investigating immune restoration, age-related immune decline, and immunotherapeutic approaches to infectious and inflammatory diseases.
Overview
Thymosin alpha-1 is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue. The peptide is a key immunoregulatory factor that enhances T cell development, maturation, and immune function. Thymosin alpha-1 is extensively studied for its potential in supporting immune competence, enhancing resistance to infections, and modulating immune responses in aging and immunocompromised states. Research indicates the peptide promotes T cell development in the thymus and enhances peripheral T cell function. Thymosin alpha-1 represents a valuable research tool for investigating immune restoration, age-related immune decline, and immunotherapeutic approaches to infectious and inflammatory diseases.
Biochemical Characteristics
Thymosin alpha-1 is a 28-amino acid peptide with molecular weight of approximately 3,108 Da. The peptide sequence contains multiple positively charged amino acids including lysine and arginine residues enabling receptor interactions. The peptide is water-soluble and stable across physiological pH ranges (6.5–8.0). Cellular uptake occurs through receptor-mediated endocytosis and peptide transporter mechanisms. Thymosin alpha-1 exhibits moderate resistance to enzymatic degradation in circulation, supporting biological half-life of several hours. The peptide localizes to thymic and lymphoid tissues where it exerts its immunomodulatory effects on T cell precursors and mature T lymphocytes.
Biochemical Characteristics
Thymosin alpha-1 is a 28-amino acid peptide with molecular weight of approximately 3,108 Da. The peptide sequence contains multiple positively charged amino acids including lysine and arginine residues enabling receptor interactions. The peptide is water-soluble and stable across physiological pH ranges (6.5–8.0). Cellular uptake occurs through receptor-mediated endocytosis and peptide transporter mechanisms. Thymosin alpha-1 exhibits moderate resistance to enzymatic degradation in circulation, supporting biological half-life of several hours. The peptide localizes to thymic and lymphoid tissues where it exerts its immunomodulatory effects on T cell precursors and mature T lymphocytes.
Research Applications
T Cell Development & Maturation Investigation of enhancement of T cell differentiation in the thymus and maturation of T cell precursors. Immune Competence Assessment of improvement in T cell proliferation and effector function in immune cells. Immunosenescence Reversal Study of restoration of age-related decline in immune function and immune cell repertoire in aging. Infection Models Examination of enhanced resistance to viral, bacterial, and opportunistic pathogen infection models. Cancer Immunotherapy Investigation of potential synergy with anti-tumor immune responses and checkpoint inhibitor therapies. Autoimmune Modulation Assessment of regulatory T cell enhancement and reduction of autoreactive immune responses. Vaccine Adjuvant Effects Study of potential enhancement of vaccine-induced immune responses and antibody production.
Research Applications
T Cell Development & Maturation Investigation of enhancement of T cell differentiation in the thymus and maturation of T cell precursors. Immune Competence Assessment of improvement in T cell proliferation and effector function in immune cells. Immunosenescence Reversal Study of restoration of age-related decline in immune function and immune cell repertoire in aging. Infection Models Examination of enhanced resistance to viral, bacterial, and opportunistic pathogen infection models. Cancer Immunotherapy Investigation of potential synergy with anti-tumor immune responses and checkpoint inhibitor therapies. Autoimmune Modulation Assessment of regulatory T cell enhancement and reduction of autoreactive immune responses. Vaccine Adjuvant Effects Study of potential enhancement of vaccine-induced immune responses and antibody production.
Pathway / Mechanistic Context
Thymic Development Support Thymosin alpha-1 enhances proliferation and differentiation of CD4+ and CD8+ T cell precursors in the thymus through interaction with thymic epithelial cells and thymocyte-supporting mechanisms. IL-2 & IL-2 Receptor Enhancement The peptide upregulates interleukin-2 (IL-2) production and IL-2 receptor expression on T cells, enhancing T cell activation and proliferation signals. Th1 Differentiation Thymosin alpha-1 promotes Th1 differentiation through enhancement of IL-12 signaling and upregulation of T-bet transcription factor, supporting cell-mediated immune responses. Natural Killer Cell Enhancement The peptide enhances NK cell function and cytotoxic activity through multiple pathways including IL-2-dependent mechanisms. Thymic Hormone Synergy Thymosin alpha-1 works synergistically with other thymic hormones including thymulin and thymopoietin to support comprehensive immune development. Antigen Presentation Enhancement The peptide enhances antigen-presenting cell function and MHC-peptide complex presentation to T cells, supporting immune recognition and activation.
Pathway / Mechanistic Context
Thymic Development Support Thymosin alpha-1 enhances proliferation and differentiation of CD4+ and CD8+ T cell precursors in the thymus through interaction with thymic epithelial cells and thymocyte-supporting mechanisms. IL-2 & IL-2 Receptor Enhancement The peptide upregulates interleukin-2 (IL-2) production and IL-2 receptor expression on T cells, enhancing T cell activation and proliferation signals. Th1 Differentiation Thymosin alpha-1 promotes Th1 differentiation through enhancement of IL-12 signaling and upregulation of T-bet transcription factor, supporting cell-mediated immune responses. Natural Killer Cell Enhancement The peptide enhances NK cell function and cytotoxic activity through multiple pathways including IL-2-dependent mechanisms. Thymic Hormone Synergy Thymosin alpha-1 works synergistically with other thymic hormones including thymulin and thymopoietin to support comprehensive immune development. Antigen Presentation Enhancement The peptide enhances antigen-presenting cell function and MHC-peptide complex presentation to T cells, supporting immune recognition and activation.
Preclinical Research Summary
Thymosin alpha-1 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of T cell-stimulatory activity available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
Thymosin alpha-1 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of T cell-stimulatory activity available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.