TB500
$
189 AUD
Product Info
TB-500 is a synthetic peptide corresponding to a sequence of thymosin beta-4, commonly used in laboratory research to study cellular migration, tissue response, and actin regulation. It is of interest in controlled experimental settings examining mechanisms related to cell repair, angiogenesis, and inflammatory pathways. TB-500 is supplied strictly for research purposes only and is not intended for human or veterinary use.
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Categories
Bacteriostatic Water
AOD
Cagrilintide
Cagrilintide + Semaglutide
Retatrutide
Semaglutide
Tirzepatide
SLU PP 332
MOTS C
BPC 157
bpc-157-tb-500
Description
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
Biochemical Characteristics
Research Applications
Pathway / Mechanistic Context
Form & Analytical Testing
RUO Disclaimer
Overview
TB-500 (thymosin beta-4) is a naturally occurring 43-amino acid peptide present throughout the body with critical roles in cell migration, cytoskeletal organization, and tissue regeneration. The peptide functions as a potent regulator of actin dynamics and supports healing, recovery, and tissue repair. TB-500 is extensively studied for its potential in accelerating wound healing, promoting tissue regeneration, enhancing musculoskeletal recovery, and supporting overall tissue integrity. Research indicates the peptide regulates actin monomer sequestration, promotes cell migration and proliferation, and enhances angiogenesis through multiple coordinated mechanisms. TB-500 represents a valuable research tool for investigating tissue repair biology, regeneration mechanisms, and therapeutic approaches to injuries and tissue damage.
Overview
TB-500 (thymosin beta-4) is a naturally occurring 43-amino acid peptide present throughout the body with critical roles in cell migration, cytoskeletal organization, and tissue regeneration. The peptide functions as a potent regulator of actin dynamics and supports healing, recovery, and tissue repair. TB-500 is extensively studied for its potential in accelerating wound healing, promoting tissue regeneration, enhancing musculoskeletal recovery, and supporting overall tissue integrity. Research indicates the peptide regulates actin monomer sequestration, promotes cell migration and proliferation, and enhances angiogenesis through multiple coordinated mechanisms. TB-500 represents a valuable research tool for investigating tissue repair biology, regeneration mechanisms, and therapeutic approaches to injuries and tissue damage.
Biochemical Characteristics
TB-500 is a 43-amino acid peptide with molecular weight of approximately 4,963 Da. The peptide exhibits high conservation across species, indicating critical biological function. TB-500 contains multiple functional domains enabling interactions with actin, growth factors, and cellular receptors. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). TB-500 distributes throughout body tissues and crosses physiological barriers efficiently. The peptide shows extended biological half-life and resistance to enzymatic degradation, supporting sustained cellular effects. Cellular uptake occurs through peptide transporter mechanisms and receptor-mediated pathways. The peptide localizes to sites of tissue injury and preferentially accumulates in regenerating tissues.
Biochemical Characteristics
TB-500 is a 43-amino acid peptide with molecular weight of approximately 4,963 Da. The peptide exhibits high conservation across species, indicating critical biological function. TB-500 contains multiple functional domains enabling interactions with actin, growth factors, and cellular receptors. The peptide is water-soluble and demonstrates excellent stability across physiological pH ranges (6.5–8.0). TB-500 distributes throughout body tissues and crosses physiological barriers efficiently. The peptide shows extended biological half-life and resistance to enzymatic degradation, supporting sustained cellular effects. Cellular uptake occurs through peptide transporter mechanisms and receptor-mediated pathways. The peptide localizes to sites of tissue injury and preferentially accumulates in regenerating tissues.
Research Applications
Wound Healing Investigation of TB-500-induced acceleration of wound closure, re-epithelialization, and healing progression. Tissue Regeneration Assessment of enhanced regeneration of skin, muscle, tendon, ligament, and connective tissues. Musculoskeletal Injury Recovery Study of accelerated recovery from muscle strain, tear, tendon injury, and ligament damage. Angiogenesis & Vascularization Investigation of enhanced new blood vessel formation and improved tissue perfusion and oxygen delivery. Collagen Synthesis Assessment of increased collagen production and extracellular matrix deposition in healing tissues. Cellular Migration & Proliferation Study of enhanced fibroblast and endothelial cell migration and proliferation through actin regulation. Inflammation Modulation Investigation of optimized inflammatory response supporting tissue healing and functional repair.
Research Applications
Wound Healing Investigation of TB-500-induced acceleration of wound closure, re-epithelialization, and healing progression. Tissue Regeneration Assessment of enhanced regeneration of skin, muscle, tendon, ligament, and connective tissues. Musculoskeletal Injury Recovery Study of accelerated recovery from muscle strain, tear, tendon injury, and ligament damage. Angiogenesis & Vascularization Investigation of enhanced new blood vessel formation and improved tissue perfusion and oxygen delivery. Collagen Synthesis Assessment of increased collagen production and extracellular matrix deposition in healing tissues. Cellular Migration & Proliferation Study of enhanced fibroblast and endothelial cell migration and proliferation through actin regulation. Inflammation Modulation Investigation of optimized inflammatory response supporting tissue healing and functional repair.
Pathway / Mechanistic Context
Actin Monomer Sequestration TB-500 binds and sequesters actin monomers (G-actin), regulating intracellular actin pools and preventing excessive actin polymerization that would inhibit cell motility and migration. Cell Migration Enhancement By controlling actin dynamics, TB-500 promotes cell migration of fibroblasts, endothelial cells, and keratinocytes essential for wound closure and tissue repair. Fibroblast Activation & Proliferation The peptide directly enhances fibroblast proliferation and promotes differentiation toward matrix-producing phenotypes critical for tissue regeneration. Angiogenic Factor Production TB-500 enhances production and secretion of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and other pro-angiogenic factors promoting new blood vessel formation. Endothelial Cell Function The peptide promotes endothelial cell proliferation, migration, and capillary tube formation through actin-dependent cytoskeletal reorganization supporting vascularization. Anti-Inflammatory & Pro-Healing Immune Modulation TB-500 promotes anti-inflammatory macrophage polarization and suppression of pro-inflammatory cytokine production, optimizing inflammatory microenvironment for tissue repair.
Pathway / Mechanistic Context
Actin Monomer Sequestration TB-500 binds and sequesters actin monomers (G-actin), regulating intracellular actin pools and preventing excessive actin polymerization that would inhibit cell motility and migration. Cell Migration Enhancement By controlling actin dynamics, TB-500 promotes cell migration of fibroblasts, endothelial cells, and keratinocytes essential for wound closure and tissue repair. Fibroblast Activation & Proliferation The peptide directly enhances fibroblast proliferation and promotes differentiation toward matrix-producing phenotypes critical for tissue regeneration. Angiogenic Factor Production TB-500 enhances production and secretion of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and other pro-angiogenic factors promoting new blood vessel formation. Endothelial Cell Function The peptide promotes endothelial cell proliferation, migration, and capillary tube formation through actin-dependent cytoskeletal reorganization supporting vascularization. Anti-Inflammatory & Pro-Healing Immune Modulation TB-500 promotes anti-inflammatory macrophage polarization and suppression of pro-inflammatory cytokine production, optimizing inflammatory microenvironment for tissue repair.
Preclinical Research Summary
TB-500 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of actin-binding and cell migration enhancement available upon request. Certificate of Analysis provided with each lot.
Preclinical Research Summary
TB-500 is supplied as sterile aqueous solution or lyophilized powder at concentrations of 1–10 mg/mL. Storage at 2–8°C; shelf-life 12–24 months for solutions, 24–36 months for lyophilized material. Analytical testing includes HPLC purity verification (≥95%), HPLC-MS molecular confirmation, amino acid analysis, and microbial sterility/endotoxin testing. Bioassay verification of actin-binding and cell migration enhancement available upon request. Certificate of Analysis provided with each lot.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
RUO Disclaimer
RESEARCH USE ONLY (RUO) This product is intended exclusively for laboratory research and is not approved for clinical use or human/animal administration. Not manufactured for pharmaceutical use. Users assume responsibility for suitability determination, proper storage, safety compliance, and regulatory adherence. Institutional approval (IACUC, IRB) may be required. Information provided is for research reference only and does not constitute medical advice or therapeutic claims.
We are committed to supporting all research customers with consistent standards and professional care.
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© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
© Standard BioLabs. All rights reserved.
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
We are committed to supporting all research customers with consistent standards and professional care.
Subscribe
Subscribe to stay updated at every moment about all our news and product drops.
Terms of Service
Refund Policy
Privacy Policy
Promotional Terms
All products on this site are designated for Research Use Only and are supplied solely for laboratory, analytical, or scientific research purposes by qualified professionals. Products are not intended for human or animal use, and no diagnostic, therapeutic, or clinical use is intended or implied.
Standard BioLabs is a chemical supplier. Standard BioLabs is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Standard BioLabs is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.
© Standard BioLabs. All rights reserved.